Changes in blood DNA methylation and incomplete adjustment for blood cell composition
نویسندگان
چکیده
منابع مشابه
Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols
Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS) using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. I...
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BACKGROUND Despite evidence linking obesity to impaired immune function, little is known about the specific mechanisms. Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized that DNA methylation changes are involved in obesity induced immune dysfunction and aimed to identify these changes. METHOD We conducted a genome wide methylation analysis on sev...
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چکیده ندارد.
15 صفحه اولDNA Methylation Dynamics in Blood after Hematopoietic Cell Transplant
Epigenetic deregulation is considered a common hallmark of cancer. Nevertheless, recent publications have demonstrated its association with a large array of human diseases. Here, we explore the DNA methylation dynamics in blood samples during hematopoietic cell transplant and how they are affected by pathophysiological events during transplant evolution. We analyzed global DNA methylation in a ...
متن کاملChanges in peripheral blood immune cell composition in osteoarthritis
OBJECTIVES Immune age-related abnormalities may synergise with osteoarthritis (OA) pathology. We explored whether abnormalities in the blood immune cell composition are present in OA, beyond defects typically associated with ageing. DESIGN Blood was collected from 121 healthy controls (HC) and 114 OA patients. Synovial biopsies were obtained from another 52 OA patients. Flow cytometry was use...
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ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2017
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dyx082